Stannanecarbonitrile, tributyl- → 1-(7-fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile

HRID 1618771Notes

Reaction equation

HRID 1618771 reaction equation
Br[C:2]1[N:7]=[C:6]2[C:8]([CH3:30])([CH3:29])[CH2:9][N:10]([C:11]3[C:20]4[C:15](=[CH:16][C:17]([F:21])=[CH:18][CH:19]=4)[N:14]=[C:13]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=4)[C:12]=3[CH3:28])[C:5]2=[CH:4][C:3]=1[N:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1.C([Sn]([C:50]#[N:51])(CCCC)CCCC)CCC>CN1C(=O)CCC1.CC(C1C=C(C(C)C)C(C2C(P(C3CCCCC3)C3CCCCC3)=CC=CC=2)=C(C(C)C)C=1)C.C1C=[C-]C(CCN)=CC=1.Cl[Pd+]>[F:21][C:17]1[CH:16]=[C:15]2[C:20]([C:11]([N:10]3[C:5]4[C:6](=[N:7][C:2]([C:50]#[N:51])=[C:3]([N:31]5[CH2:32][CH2:33][O:34][CH2:35][CH2:36]5)[CH:4]=4)[C:8]([CH3:29])([CH3:30])[CH2:9]3)=[C:12]([CH3:28])[C:13]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)=[N:14]2)=[CH:19][CH:18]=1

Participants

5

Reactant 2

HCID 200512Stannanecarbonitrile, tributyl-HCID 866642814-(5-bromo-3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-7-fluoro-3-methyl-2-(2-pyridinyl)quinoline

Product 1

HCID 509394701-(7-fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile

Reagents, catalysts & solvents 2

HCID 54751079XPhos PalladacycleCatalystHCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
140 °C

Procedure

To a stirred solution of 4-(5-bromo-3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-7-fluoro-3-methyl-2-(2-pyridinyl)quinoline (61 mg, 0.111 mmol) in NMP (1.5 mL) was added tri-n-butyltin cyanide (35.2 mg, 0.111 mmol), XPhos precatalyst (16.3 mg, 0.022 mmol) and heated at 140° C. for 2 h in the microwave. After this time the reaction was partitioned between EtOAc (60 mL) and water (30 mL). The separated organic layer was dried over MgSO4, filtered and evaporated in vacuo. Purification by reverse phase HPLC (10 to 60% acetonitrile water) gave 1-(7-fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile. 1H NMR (400 MHz, chloroform-d) δ ppm 8.68-8.80 (1H, m), 7.84-7.99 (3H, m), 7.67 (1H, dd, J=9.2, 5.9 Hz), 7.44 (1H, ddd, J=6.9, 4.9, 1.9 Hz), 7.35 (1H, ddd, J=9.2, 8.0, 2.5 Hz), 5.74 (1H, s), 3.87 (2H, s), 3.79 (4H, t, J=4.7 Hz), 2.94-3.11 (4H, m), 2.40 (3H, s), 1.59 (3H, s), 1.53 (3H, s). Mass Spectrum (ESI) m/e=495.0 (M+1).

Workup

  1. customAfter this time the reaction was partitioned between EtOAc (60 mL) and water (30 mL)
  2. dry with materialThe separated organic layer was dried over MgSO4
  3. filtrationfiltered
  4. customevaporated in vacuo
  5. customPurification by reverse phase HPLC (10 to 60% acetonitrile water)

Sources & evidence

ORD record
ord-95710f8a862a42688d81c2ad1527ea20
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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