5-Fluoro-6-methoxypyridin-3-amine → Tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(5-fluoro-6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl)piperazine-1-carboxylate
반응식
[F:1][C:2]1[CH:3]=[C:4]([NH2:10])[CH:5]=[N:6][C:7]=1[O:8][CH3:9].[CH3:11][O:12][C:13]1[CH:57]=[CH:56][C:16]([CH2:17][N:18]([CH2:47][C:48]2[CH:53]=[CH:52][C:51]([O:54][CH3:55])=[CH:50][CH:49]=2)[C:19]2[N:24]=[C:23]([CH3:25])[N:22]=[C:21]([C:26]3[CH:27]=[C:28]([CH2:33][N:34]4[CH2:39][CH2:38][N:37]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:36][CH2:35]4)[CH:29]=[N:30][C:31]=3F)[N:20]=2)=[CH:15][CH:14]=1>>[CH3:55][O:54][C:51]1[CH:50]=[CH:49][C:48]([CH2:47][N:18]([CH2:17][C:16]2[CH:56]=[CH:57][C:13]([O:12][CH3:11])=[CH:14][CH:15]=2)[C:19]2[N:24]=[C:23]([CH3:25])[N:22]=[C:21]([C:26]3[CH:27]=[C:28]([CH2:33][N:34]4[CH2:39][CH2:38][N:37]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:36][CH2:35]4)[CH:29]=[N:30][C:31]=3[NH:10][C:4]3[CH:5]=[N:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[CH:3]=3)[N:20]=2)=[CH:53][CH:52]=1참가 물질
3
반응물 2
생성물 1
실험 절차
The title compound was prepared in an analogous manner to that described in Example 155, Step 2, using 5-fluoro-6-methoxypyridin-3-amine and tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-fluoropyridin-3-yl)methyl)piperazine-1-carboxylate. tert-Butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(5-fluoro-6-methoxypyridin-3-ylamino)pyridin-3-yl)methyl)piperazine-1-carboxylate was isolated (90%) as a yellow solid. m/z (ESI, +ve ion) 765.8 (M+H)+.
후처리
- customThe title compound was prepared in an analogous manner to that
출처 및 근거
- ORD 기록
- ord-89adfb8bd0aa442f8b93dedab6d90528
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08772480B2
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