反应详情

General procedure D was followed using 1-(3,5-dichloropyridin-4-yl)piperidine-4-carboxamide (24 mg, 0.088 mmol), 4-fluorobenzene boronic acid (15 mg, 0.11 mmol) and tetrakis(triphenylphosphine)palladium(0) (5 mg, 5 mol %), acetonitrile (1 mL) and 0.5 M sodium carbonate (0.25 mL, 0.12 mmol) for 30 min. The crude product was purified by preparative tlc on silica gel (CH2Cl2, MeOH, 10:1) to give impure title compound (19 mg) which was further purified by preparative hplc (CH3CN, H2O, gradient 1:9 to 9:1) to furnish the title compound as a white solid, LC-MS (ESI, 3.5 min) Rt 1.71 min, m/z 334 (100%, [M+H]+); m/z (ESI) C17H18ClFN3O requires 334.1117 found [M+H]+ 334.1116.

1. customfor 30 min
2. customThe crude product was purified by preparative tlc on silica gel (CH2Cl2, MeOH, 10:1)