反应详情

温度

120 °C

To a scintillation vial containing N2′-(trans-4-aminocyclohexyl)-5′-chloro-N6-(3-fluorobenzyl)-2,4′-bipyridine-2′,6-diamine (10 mg, 0.023 mmol) and K2CO3 (8 mg, 0.058 mmol) was added DMSO (0.5 ml) and 2-(methylsulfonyl)ethyl methanesulfonate (30 mg). The reaction mixture was capped and heated to 120° C. in an oil bath for 4 hr. The resulting solution was purified by reverse phase preparative HPLC to yield 5′-chloro-N6-(3-fluorobenzyl)-N2′-(trans-4-(2-(methylsulfonyl)ethylamino)cyclohexyl)-2,4′-bipyridine-2′,6-diamine (3.7 mg, 24%). LCMS (m/z): 532.2 (MH+), retention time=0.62 min as a TFA salt after lypholyzing.

1. customThe reaction mixture was capped
2. customThe resulting solution was purified by reverse phase preparative HPLC