HRID1625748

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CC(=O)OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(-c4nnn(COCc5ccccc5)n4)s3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O

HCID66607043

未命名化合物

PRODUCTS

生成物

结构：OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(-c4nnn[nH]4)s3)c2)[C@H](O)[C@@H](O)[C@@H]1O

HCID178521056

未命名化合物

收率 115.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A mixture of 1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-(5-(2-benzyloxymethyl-2H-tetrazol-5-yl)-2-thienylmethyl)-4-chlorobenzene (247 mg), 6M aqueous hydrochloric acid solution (2 ml) and methanol (20 ml) was refluxed overnight. The solvent was evaporated under reduced pressure and the residue was triturated with diethyl ether to give the desired 1-(β-D-glucopyranosyl)-4-chloro-3-(5-(1H-tetrazol-5-yl)-2-thienylmethyl)benzene (172 mg) as colorless powder. ESI-Mass m/Z 437/439 (M−H).

WORKUP

后处理

temperaturewas refluxed overnight
customThe solvent was evaporated under reduced pressure
customthe residue was triturated with diethyl ether