反应详情

Method as described for example 47 using 1-(6-hydroxypyridin-2-yl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea and (S)-4-(2-chloro-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)-3-methylmorpholine (intermediate 12) as starting materials. The reaction mixture was filtered through a celite 545 pre-packed cartridge (2.5 g), washed with MeOH and reduced in vacuo. The residue was purified by prep LCMS (high pH), to yield the title compound (7.9 mg, 0.017 mmol, 9.2%).

1. filtrationThe reaction mixture was filtered through a celite 545 pre-packed cartridge (2.5 g)
2. washwashed with MeOH
3. customThe residue was purified by prep LCMS (high pH)