反应详情

温度

50 °C

1.22 g (2.8 mmol) of methyl 5-chloro-2-{[4-({[3-(furan-3-yl)phenyl]carbonyl}amino)butanoyl]amino}benzoate was dissolved in 12 mL of tetrahydrofuran (THF). 1N aqueous sodium hydroxide was added at room temperature, and the mixture was stirred at 50° C. for 1.5 hours. After cooling the mixture, 1N hydrochloric acid was added to acidify the reaction mixture, and the solvent was distilled off under reduced pressure. Thereafter, water was added to the residue. Solids were collected by filtration, followed by washing with water, thereby giving 1.07 g of the target 5-chloro-2-{[4-({[3-(furan-3-yl)phenyl]carbonyl}amino)butanoyl]amino}benzoic acid (yield: 91%).

1. additionwas added
2. distillationthe solvent was distilled off under reduced pressure
3. additionThereafter, water was added to the residue
4. filtrationSolids were collected by filtration
5. washby washing with water