3-(3-Benzyl-4-hydroxy-phenyl)-2-ethoxy-propionic acid → 3-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-2-ethoxy-propionic acid
Reaktionsgleichung
C([O:3][C:4](=[O:25])[CH:5]([O:22][CH2:23][CH3:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]([CH3:21])([CH3:20])[O:14][SiH2:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[CH:9][CH:8]=1)C.C(C1C=C(CC(OCC)C(O)=O)C=CC=1O)C1C=CC=CC=1>>[C:16]([SiH2:15][O:14][C:13]([CH3:20])([CH3:21])[C:10]1[CH:11]=[CH:12][C:7]([CH2:6][CH:5]([O:22][CH2:23][CH3:24])[C:4]([OH:25])=[O:3])=[CH:8][CH:9]=1)([CH3:18])([CH3:19])[CH3:17]Komponenten
3
Versuchsvorschrift
The title compound was prepared from 3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-ethoxy-propionic acid ethyl ester (1.1 g, 30 mmol) in the same manner as described for 3-(3-benzyl-4-hydroxy-phenyl)-2-ethoxy-propionic acid. The crude product was obtained as a solid and used in the next step without further purification (0.73 g, 65%). 1H NMR (400 MHz, CDCl3): δ 7.11-7.18 (m, 4H), 4.63 (s, 2H), 3.96-3.99 (m, 1H), 3.48-3.52 (m, 1H), 3.31-3.37 (m, 1H), 3.01-3.05 (dd, 1H), 2.87-2.92 (dd, 1H), 1.07 (t, 3H), 0.85 (s, 9H), 0.00 (s, 6H).
Quellen und Nachweise
- ORD-Eintrag
- ord-cbfcc725a9c14ed38a9cd1a3c2e58eee
- Quelldatensatz
- uspto-grants-2014_07
- Patentnummer
- US08785681B2
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