反应详情

The title compound was prepared from 2-ethoxy-3-(4-hydroxy-3-methyl-phenyl)-propionic acid benzyl ester (311 mg, 0.98 mmol) and (5-methyl-2-phenyl-oxazol-4-yl)-acetic acid (215 mg, 0.98 mmol) in the same manner as described for 3-{3-benzyl-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-acetoxy]-phenyl}-2-ethoxy-propionic acid benzyl ester. The crude product was purified by column chromatography using DCM/iPrOH (95:5) as the eluent to afford the pure product as a solid (480 mg, 94.5%). 1H NMR (400 MHz, CDCl3): δ 7.98-8.02 (m, 2H), 7.26-7.44 (m, 8H), 6.91-7.05 (m, 3H), 5.12 (s, 2H), 4.01-4.05 (t, 1H), 3.82 (s, 2H), 3.56-3.59 (m, 1H), 3.34-3.37 (m, 1H), 2.95-2.97 (d, 2H), 2.43 (s, 3H), 2.11 (s, 3H), 1.12-1.17 (t, 3H).

1. customThe crude product was purified by column chromatography