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HRID1630152

反应详情

EQUATION

反应方程式

HRID 1630152 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)O.Cl
HCID22641269

未命名化合物

结构：N[C@@H](COCc1ccc(F)cc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1
HCID67009398

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)N[C@@H](COCc1ccc(F)cc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1
HCID45378168

未命名化合物

收率 60%

PROCEDURE

实验过程

Proceeding as in Example 1, but substituting acetic acid hydrochloride and (S)-2-amino-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide, gave Compound 164, (S)-2-acetamido-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide (35 mg, 60%). 1H-NMR (400 MHz, CDCl3): δ 8.40 (s, 1H), 7.40-7.25 (m, 5H), 7.10-6.90 (m, 7H), 6.45-6.40 (m, 1H), 4.80-4.45 (m, 3H), 4.00-3.90 (m, 1H), 3.60 (m, 1H), 1.60 (s, 3H). MS (EI) for C24H22F2N2O4 found 441 (MH+).