反应详情

Proceeding as in Example 1, but substituting 2-(3-methylisoxazol-5-yl)acetic acid hydrochloride and (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 32, (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(3-methylisoxazol-5-yl)acetyl)pyrrolidine-2-carboxamide (9 mg, 29.2%). 1H-NMR (400 MHz, DMSO-D6): σ 9.97 (s, 1H), 7.54 (d, 2H), 7.27 (t, 2H), 7.19 (m, 4H), 6.67 (m, 4H), 6.20 (d, 1H), 4.48 (1H), 3.88 (m, 3H), 2.66 (m, 4H), 2.15 (s, 3H), 1.91 (m, 2H). MS (EI) for C30H28FN3O4: 514.6 (MH+).