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HRID1630243

反应详情

EQUATION

反应方程式

HRID 1630243 的结构方程式

REACTANTS

反应物

2
结构：Cl.O=C(O)Cn1cncn1
HCID44887050

1H-1,2,4-Triazole-1-acetic acid, monohydrochloride

C4H6ClN3O2

结构：Cc1ccc(C[C@H]2CN[C@H](C(=O)Nc3ccc(Oc4ccc(F)cc4)cc3)C2)cc1
HCID67010239

(2S,4R)-N-(4-(4-fluorophenoxy)phenyl)-4-(4-methylbenzyl)pyrrolidine-2-carboxamide

C25H25FN2O2

PRODUCTS

生成物

1
结构：Cc1ccc(C[C@@H]2C[C@@H](C(=O)Nc3ccc(Oc4ccc(F)cc4)cc3)NC2C(=O)Cn2cncn2)cc1
HCID46191335

未命名化合物

PROCEDURE

实验过程

Proceeding as in Example 1, but substituting 2-(1H-1,2,4-triazol-1-yl)acetic acid hydrochloride and (2S,4R)—N-(4-(4-fluorophenoxy)phenyl)-4-(4-methylbenzyl)pyrrolidine-2-carboxamide, gave Compound 4, (2S,4R)-5-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(4-methylbenzyl)pyrrolidine-2-carboxamide. 1H-NMR (400 MHz, CDCl3): σ 9.02 (br s, 1H), 8.23 (s, 1H), 7.98 (s, 1H), 7.40 (m, 2H), 7.12 (d, 2H), 7.08 (d, 2H), 7.03-6.98 (m, 2H), 6.94-6.87 (m, 4H), 4.98 (dd, 2H), 4.78 (d, 1H), 3.62 (m, 1H), 3.23 (t, 1H), 3.02-2.87 (m, 2H), 2.65-2.60 (m, 2H), 2.34 (s, 3H), 1.74-1.66 (m, 1H); MS (EI) for C29H28FN5O3. found 514.1 (MH+).