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HRID1630249

反应详情

EQUATION

反应方程式

HRID 1630249 的结构方程式

REACTANTS

反应物

2
结构：Cl.O=C(O)Cn1cncn1
HCID44887050

1H-1,2,4-Triazole-1-acetic acid, monohydrochloride

C4H6ClN3O2

结构：COc1cccc(C[C@H]2CN[C@H](C(=O)Nc3ccc(Oc4ccc(F)cc4)cc3)C2)c1
HCID67010644

未命名化合物

PRODUCTS

生成物

1
结构：COc1cccc(C[C@@H]2C[C@@H](C(=O)Nc3ccc(Oc4ccc(F)cc4)cc3)N(C(=O)Cn3cncn3)C2)c1
HCID46191403

未命名化合物

收率 82%

PROCEDURE

实验过程

Proceeding as in Example 1, but substituting 2-(1H-1,2,4-triazol-1-yl)acetic acid hydrochloride and (2S,4R)—N-(4-(4-fluorophenoxy)phenyl)-4-(3-methoxybenzyl)pyrrolidine-2-carboxamide, gave Compound 70, (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(3-methoxybenzyl)pyrrolidine-2-carboxamide (160 mg, 82%). 1H-NMR (400 MHz, CDCl3): σ 9.00 (s, 1H), 8.23 (s, 1H), 7.99 (s, 1H), 7.41 (d, 2H), 7.00 (t, 2H), 6.93-6.89 (m, 4H), 6.80-6.73 (m, 4H), 5.03 (d, 1H), 4.95 (d, 1H), 4.80 (d, 1H), 3.81 (s, 3H), 3.63 (dd, 1H), 3.27-3.16 (m, 1H), 3.02-2.88 (m, 2H), 2.68-2.59 (m, 2H), 1.76-1.68 (m, 1H). MS (EI) for C29H28FN5O4. found 530.2 (MH+).