反应详情

Proceeding as in Example 1, but substituting 2-(1H-1,2,3-triazol-1-yl)acetic acid hydrochloride and (2S,4S)-4-((5-chlorothien-2-yl)methyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 65, (2S,4S)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-4-((5-chlorothien-2-yl)methyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide (60.2 mg, 65%). 1H-NMR (400 MHz, CDCl3): σ 8.95 (s, 1H), 7.77 (d, 2H), 7.43 (d, 2H), 7.00 (t, 2H), 6.94-6.89 (m, 4H), 6.76 (d, 1H), 6.63 (d, 1H), 5.30 (d, 1H), 5.17 (d, 1H), 4.80 (d, 1H), 3.79 (dd, 1H), 3.30 (t, 1H), 3.04-2.93 (m, 2H), 2.87-2.78 (m, 1H), 2.68 (dd, 1H), 1.75-1.68 (m, 1H). MS (EI) for C26H23ClFN5O3S. found 540.1 (MH+).