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HRID1630255

反应详情

EQUATION

反应方程式

HRID 1630255 的结构方程式

REACTANTS

反应物

2
结构：Cl.O=C(O)Cn1nccn1
HCID67009497

未命名化合物

结构：O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccc(F)cc2Cl)CN1
HCID67010674

未命名化合物

PRODUCTS

生成物

1
结构：O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)[C@@H]1C[C@@H](Cc2ccc(F)cc2Cl)CN1C(=O)Cn1nccn1
HCID46191401

(2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-(2-chloro-4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide

C28H24ClF2N5O3

PROCEDURE

实验过程

Proceeding as in Example 1, but substituting 2-(2H-1,2,3-triazol-2-yl)acetic acidhydrochloride and (2S,4R)-4-(2-chloro-4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide, gave Compound 5, (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-(2-chloro-4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide. 1H-NMR (400 MHz, CDCl3): δ 9.15 (s, 1H), 7.70 (s, 2H), 7.40-7.36 (m, 2H), 7.23-7.12 (m, 2H), 7.02-6.84 (m, 7H), 5.31 (s, 2H), 4.80 (d, 1H), 3.62-3.57 (m, 1H), 3.24 (t, 1H), 3.04-2.95 (m, 1H), 2.90-2.85 (m, 1H), 2.53 (dd, 1H), 1.79-1.70 (m, 1H). MS (EI) for C28H25ClF2N5O3 found 552 (MH+).