1-Fluoro-2-methylpropan-2-amine → HCID 67500746, compound

HRID 1631361Notes

Reaction equation

HRID 1631361 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[C:15]2[CH:20]=[CH:19][N:18]3[N:21]=[CH:22][C:23]([C:24](O)=[O:25])=[C:17]3[N:16]=2)[C:5]([O:8][CH3:9])=[N:6][CH:7]=1.[F:27][CH2:28][C:29]([CH3:32])([NH2:31])[CH3:30]>>[F:1][C:2]1[CH:3]=[C:4]([C@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[C:15]2[CH:20]=[CH:19][N:18]3[N:21]=[CH:22][C:23]([C:24]([NH:31][C:29]([CH3:32])([CH3:30])[CH2:28][F:27])=[O:25])=[C:17]3[N:16]=2)[C:5]([O:8][CH3:9])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 139352501-Fluoro-2-methylpropan-2-amineHCID 66847769HCID 66847769, compound

Product 1

HCID 67500746HCID 67500746, compoundYield 78%

Procedure

Prepared by the method described in Example 1 using (R)-5-(2-(5-fluoro-2-methoxypyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Preparation K) and 1-fluoro-2-methylpropan-2-amine. The combined organic extracts were concentrated and the residue was purified by reverse phase HPLC (0-90% acetonitrile/water) to provide the title compound (28 mg, 78% yield). MS (apci) m/z=431.0 (M+H).

Workup

  1. customPrepared by the method
  2. concentrationThe combined organic extracts were concentrated
  3. customthe residue was purified by reverse phase HPLC (0-90% acetonitrile/water)

Sources & evidence

ORD record
ord-97fdbb4a8c954314956ae28e68db4837
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

Loading…