Ethyl Acetate → [(3S,5R)-5-(3,4,5-trifluorophenyl)morpholin-3-yl]methanol

A 4 N hydrochloric acid-ethyl acetate solution (30 mL) was added to an ethyl acetate solution (30 mL) of {(S)-1-benzyloxymethyl-2-[2-oxo-2-(3,4,5-trifluorophenyl)ethoxy]ethyl}carbamic acid tert-butyl ester (3.55 g) at room temperature. The resulting reaction solution was stirred at room temperature for 1 hr and then concentrated under reduced pressure. To a methanol solution (50 mL) of the obtained residue, 10% palladium-carbon (containing 50% water, 167 mg) was added. The resulting reaction solution was stirred in hydrogen atmosphere at room temperature for 18 hr, and the palladium carbon in the reaction solution was removed by filtration. The filtrate was concentrated under reduced pressure, and a saturated sodium hydrogencarbonate aqueous solution and ethyl acetate were added thereto. The organic layer was separated, washed with saturated saline, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluting solvent: heptane-ethyl acetate system) to give 1.52 g of the title compound. The physical property values of this compound were as follows:

1. customThe resulting reaction solution
2. concentrationconcentrated under reduced pressure
3. additionTo a methanol solution (50 mL) of the obtained residue, 10% palladium-carbon (containing 50% water, 167 mg) was added
4. customThe resulting reaction solution
5. customthe palladium carbon in the reaction solution was removed by filtration
6. concentrationThe filtrate was concentrated under reduced pressure
7. additiona saturated sodium hydrogencarbonate aqueous solution and ethyl acetate were added
8. customThe organic layer was separated
9. washwashed with saturated saline
10. dry with materialdried over anhydrous magnesium sulfate
11. concentrationconcentrated under reduced pressure
12. customThe residue was purified by silica gel column chromatography (eluting solvent: heptane-ethyl acetate system)

ORD record

ord-6b19494e75424e0a9ec2808e38255079

Source dataset

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07737141B2