反应详情

A 50 mg portion of 6-amino-5-chloro-2-(4-methyl-1-piperazinyl)benzoxazole was dissolved in 5 ml of DMF, and the solution, while stirring at room temperature, was mixed with 135 mg of allyl bromide and stirred for additional 2 hours. Thereafter, the solvent was evaporated under a reduced pressure and the thus obtained mixture was purified by an LH-20 gel column chromatography (chloroform:methanol=1:1) to obtain the title compound (15 mg) in light yellow color. 1H-NMR (CD3OD) δ values: 3.17 (3 H, s), 3.5-3.7 (4 H, m), 3.8-4.2 (4 H, m), 4.13 (2 H, d), 5.65-5.8 (2 H, m), 6.0-6.15 (1 H, m), 6.93 (1 H, s), 7.20 (1 H, s); MS (EI): m/z 306 (M+)

1. stirringstirred for additional 2 hours
2. customThereafter, the solvent was evaporated under a reduced pressure
3. customthe thus obtained mixture was purified by an LH-20 gel column chromatography (chloroform:methanol=1:1)