反应详情

1-(4-Methoxyphenyl)-2(1H,3H)-indolone (49 g, 0.205 mole), N-methyl-2-pyrrolidone dimethyl acetal (ca. 80%, 53 g, 0.245 mole, Ber, 97, pp. 3081-7, 1964) and 1000 ml chloroform were refluxed under nitrogen for 1.5 hours. The reaction mixture was cooled and evaporated in vacuo to solids. Two recrystallizations from ethyl acetate gave purified title product, 44.7 g, m.p. 90°-93° C. Thirty grams of this material were dried at 80° C./15 mm Hg for 20 hours to give 26.1 g of title product, m.p. 127°-9° C.

1. temperatureThe reaction mixture was cooled
2. customevaporated in vacuo to solids
3. customTwo recrystallizations from ethyl acetate
4. customgave
5. custompurified title product, 44.7 g, m.p. 90°-93° C
6. dry with materialThirty grams of this material were dried at 80° C./15 mm Hg for 20 hours