反应详情

2,2,2-Trifluoroethanol and 3,5-dibromopyridine were processed as described in Example 7A except that the heating time was extended to 20 hours at 100° C. The reaction was quenched onto ice/water, extracted with ethyl ether, and concentrated. The residue was purified on silica gel (hexanes:ethyl acetate, 8:2) to provide the title compound as a colorless oil (70% yield). MS (DCI/NH3) m/z 256/258 (M+H)+.

1. customThe reaction was quenched onto ice/water
2. extractionextracted with ethyl ether
3. concentrationconcentrated
4. customThe residue was purified on silica gel (hexanes:ethyl acetate, 8:2)