HRID1642503

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4131669

2-Butyn-1-yl chloroformate

C5H5ClO2

结构：CC1(N2CCC(N3C(=O)N[C@H]4CCCC[C@@H]43)CC2)CCNC1

HCID57619793

未命名化合物

PRODUCTS

生成物

结构：CC#CCOC(=O)N1CCC(C)(N2CCC(N3C(=O)N[C@H]4CCCC[C@@H]43)CC2)C1

HCID25221450

未命名化合物

收率 33.9%

PROCEDURE

实验过程

Following the procedure used in example 16 and starting from (3aS,7aS)-3-[1-(3-methylpyrrolidin-3-yl)-4-piperidyl]-3a,4,5,6,7,7a-hexahydro-1H-benzimidazol-2-one (HCl salt, 0.6 g, 1.75 mmol) and but-2-ynyl chloroformate (0.218 mL, 1.92 mmol), the title compound (0.239 g, 33.9%) was obtained after purification by preparative LC/MS (high pH) as a mixture of diastereomers. MS (M+1): 403.3