反应详情

温度

-20 °C

5-iso-Butyl-N-tert-butylthiophene-2-sulfonamide (10.6 g, 0.039 mol, see step (b)) above) was dissolved in THF (165 mL) under N2 and then cooled to −78° C. n-BuLi (1.6 M, 60.19 mL, 0.096 mol) was added via a syringe. The reaction mixture was stirred at −20° C. for 4 h. The tri-iso-propylborate (13.3 mL, 0.058 mol) was then added via a syringe and the reaction mixture was stirred overnight at room temperature. The reaction was quenched with 2 M HCl (20 mL). The organic phase was separated and the water phase was extracted with EtOAc (3×100 mL). The combined organic phase was washed with brine, dried and concentrated in vacuo. The product was used without further purification.

1. additionwas added via a syringe
2. stirringthe reaction mixture was stirred overnight at room temperature
3. customThe reaction was quenched with 2 M HCl (20 mL)
4. customThe organic phase was separated
5. extractionthe water phase was extracted with EtOAc (3×100 mL)
6. washThe combined organic phase was washed with brine
7. customdried
8. concentrationconcentrated in vacuo
9. customThe product was used without further purification