反应详情

A mixture containing 25 g of 6-methyl-5-(n-propanoyl)-2-(1H)-pyridinone, 200 ml of dimethylformamide and 25 ml of dimethylformamide dimethyl acetal was heated on a steam bath for 5 and 1/2 hours and the dimethylformamide was removed by heating the reaction mixture on a rotary evaporator. The residue was refluxed with 100 ml of ethanol, the mixture cooled, and the yellow solid was collected, washed with ethanol and dried in an oven at 90°-95° C. to yield 12.8 g of 6-(2-dimethylaminoethenyl)-5-(n-propanoyl)-2(1H)-pyridinone, m.p. 204°-206° C.

1. temperaturewas heated on a steam bath for 5 and 1/2 hours
2. customthe dimethylformamide was removed
3. temperatureby heating the reaction mixture
4. customon a rotary evaporator
5. temperatureThe residue was refluxed with 100 ml of ethanol
6. temperaturethe mixture cooled
7. customthe yellow solid was collected
8. washwashed with ethanol
9. customdried in an oven at 90°-95° C.