反应详情

温度

80 °C

A 2 g. portion of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]-thiophene was suspended in 35 ml. of chloroform, and 3.5 g. of potassium carbonate was added. The flask was blanketed with nitrogen, and 2 mg. of 4-dimethylaminopyridine and 1.2 g. of benzoyl chloride were added. The mixture was heated in an 80° C. oil bath for 4 hours under reflux, and was then poured into a large amount of aqueous sodium chloride solution. The mixture was then extracted three times with 50 ml. portions of chloroform, and the organic layers were combined and washed with aqueous sodium chloride solution and dried over magnesium sulfate. The solution was then filtered, and hydrogen chloride gas was bubbled through it. Solvent was then removed under vacuum, leaving a gray oil, which was triturated with denatured alcohol and seeded with an authentic sample of the desired product to obtain white crystals, which were washed with diethyl ether and recrystallized from dichloromethane/ethanol to obtain 1.86 g. of the desired product, m.p. 235°-236° C.

1. temperatureunder reflux
2. extractionThe mixture was then extracted three times with 50 ml
3. washwashed with aqueous sodium chloride solution
4. dry with materialdried over magnesium sulfate
5. filtrationThe solution was then filtered
6. customhydrogen chloride gas was bubbled through it
7. customSolvent was then removed under vacuum
8. customleaving a gray oil, which
9. customwas triturated with denatured alcohol
10. customto obtain white crystals, which
11. washwere washed with diethyl ether
12. customrecrystallized from dichloromethane/ethanol
13. customto obtain 1.86 g