反应详情

There was dissolved 0.20 g of ethyl-α-(1-carboxyethyl)amino-γ-oxo-γ-phenylbutyrate prepared in Example 10 into 11.0 ml of 1% (v/v) H2SO4 -EtOH, to which 0.05 g of 10% Pd/C was added and the hydrogenation reaction was carried out at room temperature under atmospheric pressure. After completion of the reaction, the catalyst was filtered off with suction and the ethanol solution was neutralized with sodium hydroxide, followed by distillation of the solvent under reduced pressure. The residue was dissolved in water and extracted with dichloromethane, the organic layer being concentrated under reduced pressure. The residue was crystallized from ethyl acetate to give 0.152 g of ethyl-α-(1-carboxyethyl)amino-γ-phenylbutyrate ((αS,1S)-form/(αR,1S)-form=99/1).

1. customthe hydrogenation reaction
2. customwas carried out at room temperature under atmospheric pressure
3. customAfter completion of the reaction
4. filtrationthe catalyst was filtered off with suction
5. distillationfollowed by distillation of the solvent under reduced pressure
6. dissolutionThe residue was dissolved in water
7. extractionextracted with dichloromethane
8. concentrationthe organic layer being concentrated under reduced pressure
9. customThe residue was crystallized from ethyl acetate