Sodium Hydroxide → HCID 178441549, compound

HRID 1655114Notes

Reaction equation

HRID 1655114 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[N:10]=[C:11]([CH2:31][CH2:32][CH2:33][CH3:34])[N:12]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[C:26]4[NH:30][N:29]=[N:28][N:27]=4)=[CH:16][CH:15]=3)[C:6]=2[CH:5]1[C:35]([O:37]C)=[O:36])(=[O:3])[CH3:2].[OH-].[Na+:40]>CO>[Na+:40].[Na+:40].[CH2:31]([C:11]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:6]2[CH:5]([C:35]([O-:37])=[O:36])[N:4]([C:1](=[O:3])[CH3:2])[CH2:9][CH2:8][C:7]=2[N:10]=1)[CH2:32][CH2:33][CH3:34].[CH2:31]([C:11]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:6]2[CH:5]([C:35]([O-:37])=[O:36])[N:4]([C:1](=[O:3])[CH3:2])[CH2:9][CH2:8][C:7]=2[N:10]=1)[CH2:32][CH2:33][CH3:34]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178441544HCID 178441544, compound

Product 1

HCID 178441549HCID 178441549, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of the compound obtained in Example 4 (142 mg), 1N aqueous sodium hydroxide solution (0.60 ml) and methanol (5 ml) is stirred at room temperature overnight, and evaporated under reduced pressure to remove the solvent. The resulting residue is purified by column chromatography of nonionic adsorbing resin (tradename; NP-20, manufactured by Mitsubishi Kasei Corporation, Japan), and lyophilized to give 2-n-butyl-5-acetyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylic acid disodium salt (100 mg).

Workup

  1. customevaporated under reduced pressure
  2. customto remove the solvent
  3. customThe resulting residue is purified by column chromatography of nonionic adsorbing resin (tradename; NP-20, manufactured by Mitsubishi Kasei Corporation, Japan)

Sources & evidence

ORD record
ord-d1a77c841e2741b9b00beb3a9ca964e6
Source dataset
uspto-grants-1995_04
Patent number
US05409936

Reaction notes

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