HRID1655114

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CCCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(C(=O)OC)N(C(C)=O)CC2

HCID178441544

未命名化合物

PRODUCTS

生成物

结构：CCCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(C(=O)[O-])N(C(C)=O)CC2.CCCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(C(=O)[O-])N(C(C)=O)CC2.[Na+].[Na+]

HCID178441549

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A mixture of the compound obtained in Example 4 (142 mg), 1N aqueous sodium hydroxide solution (0.60 ml) and methanol (5 ml) is stirred at room temperature overnight, and evaporated under reduced pressure to remove the solvent. The resulting residue is purified by column chromatography of nonionic adsorbing resin (tradename; NP-20, manufactured by Mitsubishi Kasei Corporation, Japan), and lyophilized to give 2-n-butyl-5-acetyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylic acid disodium salt (100 mg).

WORKUP

后处理

customevaporated under reduced pressure
customto remove the solvent
customThe resulting residue is purified by column chromatography of nonionic adsorbing resin (tradename; NP-20, manufactured by Mitsubishi Kasei Corporation, Japan)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d1a77c841e2741b9b00beb3a9ca964e6
来源数据集: uspto-grants-1995_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05409936
来源说明: uspto-grants-1995_04

反应 SMILES

[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[N:10]=[C:11]([CH2:31][CH2:32][CH2:33][CH3:34])[N:12]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[C:26]4[NH:30][N:29]=[N:28][N:27]=4)=[CH:16][CH:15]=3)[C:6]=2[CH:5]1[C:35]([O:37]C)=[O:36])(=[O:3])[CH3:2].[OH-].[Na+:40]>CO>[Na+:40].[Na+:40].[CH2:31]([C:11]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:6]2[CH:5]([C:35]([O-:37])=[O:36])[N:4]([C:1](=[O:3])[CH3:2])[CH2:9][CH2:8][C:7]=2[N:10]=1)[CH2:32][CH2:33][CH3:34].[CH2:31]([C:11]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:6]2[CH:5]([C:35]([O-:37])=[O:36])[N:4]([C:1](=[O:3])[CH3:2])[CH2:9][CH2:8][C:7]=2[N:10]=1)[CH2:32][CH2:33][CH3:34]