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HRID1655730

反应详情

EQUATION

反应方程式

HRID 1655730 的结构方程式

REACTANTS

反应物

2
结构：C=C[C@@H](C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](CC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)Cc1ccccc1)C(C)C
HCID178456009

未命名化合物

结构：C=C[C@@H](C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)Cc1ccccc1)C(C)C
HCID178456010

未命名化合物

PRODUCTS

生成物

2
结构：CC[C@@H](C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](CC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)Cc1ccccc1)C(C)C
HCID178456011

未命名化合物

结构：CC[C@@H](C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)Cc1ccccc1)C(C)C
HCID178456012

未命名化合物

PROCEDURE

实验过程

In a manner analogous to that described in Example 2, by catalytically hydrogenating t-butyl (S)-2-[[(S)-α-[[(S)-1-[[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-5-hexenyl]carbamoyl]-2-imidazol-4-ylethyl]-carbamoyl]-phenethyl]acetyl]-1-pyrrolidinecarboxylate and t-butyl (S)-2-[[(R)-α-[[(S)-1-[[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-5-hexenyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]phenethyl]acetyl]-1-pyrrolidinecarboxylate, there was obtained t-butyl (S)-2-[[(S)-α-[[(S)-1-[[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropylhexyl]carbamoyl]-2-imidazol-4-ylethyl]-carbamoyl]phenethyl]acetyl]-1-pyrrolidinecarboxylate (less polar isomer) and t-butyl (S)-2-[[(R)-α-[[(S)-1-[[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropylhexyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]phenethyl]-acetyl]-1-pyrrolidinecarboxylate. MS: 736 (M+H)+