反应详情

Ethyl 2-(4-cyanomethyl-3,4-dihydro-3-oxo-2H-1,4-benzothiazin-2-yl)acetate (580 mg) and 474 mg of 2-amino-4,6-difluorothiophenol hydrochloride were added to 4 ml of anhydrous ethanol, the mixture was heated to reflux under argon atmosphere. After 15 hours, the solvent was distilled off. Water was added to the mixture, and extracted with ethyl acetate. After the drying of the organic layer over anhydrous magnesium sulfate, the solvent was distilled off. The resulting oily matter was subjected to alumina column chromatography. Elution with hexane-ehtyl acetate gave 660 mg of the title compound. The structural formula and physical data of this compound are shown in Table 19.

1. temperaturethe mixture was heated
2. temperatureto reflux under argon atmosphere
3. distillationthe solvent was distilled off
4. additionWater was added to the mixture
5. extractionextracted with ethyl acetate
6. dry with materialAfter the drying of the organic layer over anhydrous magnesium sulfate
7. distillationthe solvent was distilled off
8. washElution with hexane-ehtyl acetate