N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-[[4-(4,5,6,7-tetrahydrobenzofuran-2-yl)]phenoxy]propanamine hydrochloride → 2-Aminotetralin

HRID 1656621Notes

Reaction equation

HRID 1656621 reaction equation
O1C2CCCCC=2C=C1C1C=CC(OCC2OC2)=CC=1.Cl.[CH2:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:25][CH2:24][CH:23]1[NH:32]CC(O)COC1C=CC(C2OC3CCCCC=3C=2)=CC=1>C(O)C>[NH2:32][CH:23]1[CH2:24][CH2:25][C:26]2[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:22]1

Participants

4

Reactant 2

HCID 14750973N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-[[4-(4,5,6,7-tetrahydrobenzofuran-2-yl)]phenoxy]propanamine hydrochlorideHCID 197882584-(4,5,6,7-Tetrahydrobenzofuran-2-yl)-1-(2,3-epoxypropoxy)benzene

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the procedure of Example 27, but starting from 4-(4,5,6,7-tetrahydrobenzofuran-2-yl)-1-(2,3-epoxypropoxy)benzene (27 g), obtained according to the teaching of U.S. Pat. No. 3,894,058, and 2-aminotetralin (14.85 g) in ethanol (150 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-[[4-(4,5,6,7-tetrahydrobenzofuran-2-yl)]phenoxy]propanamine hydrochloride is obtained ((i): R=H, Ar=radical 31 wherein Z is H, and the chain is attached to position 2 of the tetralin moiety).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-a4de43d371ff4ef69ee30b853ce9adfb
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

Loading…