4-(2,3-Epoxypropoxy)-1-oxoindane → 2-Aminotetralin

HRID 1656624Notes

Reaction equation

HRID 1656624 reaction equation
O1CC1COC1C=CC=C2C=1CCC2=O.Cl.[CH2:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20][CH2:19][CH:18]1[NH:27]CC(O)COC1C=CC=C2C=1CCC2=O>C(O)C>[NH2:27][CH:18]1[CH2:19][CH2:20][C:21]2[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:17]1

Participants

4

Reactant 2

HCID 128311224-(2,3-Epoxypropoxy)-1-oxoindaneHCID 14750981HCID 14750981, compound

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the procedure of Example 27, but starting from 4-(2,3-epoxypropoxy)-1-oxoindane (18.8 g, see JP 49-048649) and 2-aminotetralin (14.81 g) in absolute ethanol (120 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(1-oxoindan-4-yloxy)propanamine hydrochloride is obtained ((i): R=H, Ar=radical 35, and the chain is attached to position 2 of the tetralin moiety).

Sources & evidence

ORD record
ord-a25665ad30b44467948ed20a354b2ef8
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

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