反应详情

Following the procedure of Example 27, but starting from 4-(2,3-epoxypropoxy)-1-oxoindane (18.8 g, see JP 49-048649) and 2-aminotetralin (14.81 g) in absolute ethanol (120 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(1-oxoindan-4-yloxy)propanamine hydrochloride is obtained ((i): R=H, Ar=radical 35, and the chain is attached to position 2 of the tetralin moiety).