反应详情

温度

50 °C

2-Benzhydryloxycarbonyl-7-[2-methoxyimino-2-(2-tritylamino-thiazol-4-yl)-acetamido]-8-oxo-3-(2-tosyloxyvinyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene (syn isomer, E-form) 1.5 g) is dissolved in a mixture of formic acid (30 cc) and distilled water (10 cc). The solution is heated at 50° C. for 30 minutes. After cooling, the precipitate is filtered off and the filtrate is concentrated to dryness under reduced pressure (10 mm Hg) at 30° C. The residue is triturated with diethyl ether (50 cc). The solidifed product is filtered off, washed with diethyl ether (2×25 cc) and then dried under reduced pressure (5 mm Hg) at 25° C. 7-[2-(2-Amino-thiazol-4-yl)-2-methoxyimino-acetamido]-2-carboxy-8-oxo-3-(2-tosyloxyvinyl)-5-thia-1-aza-bicyclo[4.2.0]-oct-2-ene (syn isomer, E-form) (0.75 g) is obtained as a solvate with formic acid.

1. distillationdistilled water (10 cc)
2. temperatureAfter cooling
3. filtrationthe precipitate is filtered off
4. concentrationthe filtrate is concentrated to dryness under reduced pressure (10 mm Hg) at 30° C
5. customThe residue is triturated with diethyl ether (50 cc)
6. filtrationThe solidifed product is filtered off
7. washwashed with diethyl ether (2×25 cc)
8. customdried under reduced pressure (5 mm Hg) at 25° C