反应详情

温度

-100 °C

Under an atmosphere of argon, tert-butyllithium (1.7 M in pentane) (0.576 mL, 0.98 mmol) was added dropwise to anhydrous tetrahydrofuran (4.00 mL) at −100° C. 4-Bromo-2-cyclopropylpyridine (0.097 g, 0.49 mmol) in anhydrous THF (2.00 mL) was added dropwise to the mixture. The solution was stirred for 2 minutes before dropwise addition of a solution of N-((2-bromopyridin-4-yl)(2-cyano-3-fluorophenyl)methylene)-2-methylpropane-2-sulfinamide (0.200 g, 0.49 mmol) in anhydrous THF (2.00 mL). The reaction was stirred at −100° C. for 20 minutes, then the temperature was raised to −78° C. over a period of 10 minutes. The reaction was stirred at −78° C. for another 60 minutes. MeOH (2.0 mL) was added dropwise at −78° C. followed by hydrogen chloride (1.25 M in methanol) (1.176 mL, 1.47 mmol). The cooling bath was removed and the reaction was left to stir at ambient temperature for 60 minutes. The solvents were evaporated and the residue was partitioned between EtOAc and saturated aqueous NaHCO3. The aqueous layer was extracted with EtOAc (×2), the organics were combined, dried (Na2SO4), filtered and evaporated. Purification by silica chromatography using 0 to 5% (3.5 M ammonia in methanol) in dichloromethane gave the title compound (0.094 g, 45%).

1. temperaturethe temperature was raised to −78° C. over a period of 10 minutes
2. stirringThe reaction was stirred at −78° C. for another 60 minutes
3. customThe cooling bath was removed
4. waitthe reaction was left
5. stirringto stir at ambient temperature for 60 minutes
6. customThe solvents were evaporated
7. customthe residue was partitioned between EtOAc and saturated aqueous NaHCO3
8. extractionThe aqueous layer was extracted with EtOAc (×2)
9. dry with materialdried (Na2SO4)
10. filtrationfiltered
11. customevaporated
12. customPurification by silica chromatography