反应详情

(3R)-3-(3-(((2-((1R)-2,2-Dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid or (3R)-3-(3-(((2-((1S)-2,2-dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid or (3S)-3-(3-(((2-((1R)-2,2-dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid or (3S)-3-(3-(((2-((1S)-2,2-dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid (78.5). The title compound was prepared from chloromethyl compound 78.5F or 78.5G derived from 78.5E (peak two from the separation of the racemic alcohol) using the methods described herein. MS ESI (pos.) m/e: 504.2 (M+H2O)+, 509.2 (M+Na)+.

1. customfrom the separation of the racemic alcohol)