反应详情

A mixture of 1-(2-bromo-5-fluorophenyl)-4-methyl-1H-1,2,4-triazol-5(4H)-one (0.484 g, 1.78 mmol), CuCN (0.319 g, 3.56 mmol), and 8 mL of NMP was subjected to microwave irradiation at 120° C. for 3 h. The brown mixture was filtered over Celite® and washed with DMF. This solution was treated with 10% aqueous NH4OH (28-30% solution) and extracted with EtOAc. The combined organic fractions were successively washed with 10% aqueous NH4OH (28-30% solution), saturated aqueous NH4Cl, water, brine and dried over Na2SO4. The resulting mixture was concentrated in vacuo and the residue was purified with a Biotage column chromatography system on silica gel with hexanes:ethyl acetate (3:7 to 2:8) gradient as the eluent to afford the title compound as a pink solid (0.305 g, 79% yield): 1H NMR (400 MHz, CDCl3) δ 7.76 (1H, dd, J=8.8, 5.8 Hz), 7.72 (1H, dd, J=9.6, 2.5 Hz), 7.64 (1H, s), 7.10 (1H, ddd, J=8.7, 7.4, 2.7 Hz), 3.40 (3H, s); LCMS (+ESI, M+H+) m/z 219.

1. customirradiation at 120° C. for 3 h
2. filtrationThe brown mixture was filtered over Celite®
3. washwashed with DMF
4. additionThis solution was treated with 10% aqueous NH4OH (28-30% solution)
5. extractionextracted with EtOAc
6. washThe combined organic fractions were successively washed with 10% aqueous NH4OH (28-30% solution), saturated aqueous NH4Cl, water, brine
7. dry with materialdried over Na2SO4
8. concentrationThe resulting mixture was concentrated in vacuo
9. customthe residue was purified with a Biotage column chromatography system on silica gel with hexanes:ethyl acetate (3:7 to 2:8) gradient as the eluent