反应详情

Benzyl 3-methyl-2-oxo-2,2′,3,3′-tetrahydro-1H,1′H-spiro[1,8-naphthyridine-4,4′-pyridine]-1′-carboxylate (73 mg, 0.20 mmol) was diluted in ethanol (10 mL) and palladium (10% on carbon; 100 mg) was added. The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (1 atm). After 6 h, the mixture was filtered with celite, washed with ethanol and methanol. The filtrate was concentrated to give the title compound. MS 232.1 (M+1).

1. customThe reaction vessel was evacuated
2. additionback-filled with nitrogen (3×)
3. additionback-filled with hydrogen (1 atm)
4. filtrationthe mixture was filtered with celite
5. washwashed with ethanol and methanol
6. concentrationThe filtrate was concentrated