反应详情

温度

60 °C

8-Methoxy-2-(2-methoxyethoxy)adenine (3.27 g, 13.7 mmol) was dissolved in DMF (75 ml), and thereto were added potassium carbonate (1.89 g, 13.7 mmol) and 4-[2-(methanesulfonyloxy)ethyl]piperidine-1-carboxylic acid tert-butyl ester (4.21 g, 13.7 mmol), and the mixture was stirred at 60° C. for 2.5 hours. The mixture was cooled to room temperature, and the carbonate salt was removed by filtration, and the filtrate was concentrated. To the residue was added water, and the mixture was extracted three times with chloroform. The resultant was dried over magnesium sulfate, and concentrated. The residue was purified by silica gel column (chloroform/methanol=200/1 to 100/1) to give the subtitle compound (3.62 g, 8.04 mmol) as a white solid. Yield: 60%.

1. temperatureThe mixture was cooled to room temperature
2. customthe carbonate salt was removed by filtration
3. concentrationthe filtrate was concentrated
4. additionTo the residue was added water
5. extractionthe mixture was extracted three times with chloroform
6. dry with materialThe resultant was dried over magnesium sulfate
7. concentrationconcentrated
8. customThe residue was purified by silica gel column (chloroform/methanol=200/1 to 100/1)