反应详情

The title compound was prepared using the procedure described in Example 172 substituting 2-(2-oxo-3-(4-(trifluoromethyl)phenyl)pyrrolidin-1-yl)acetic acid from Example 266D for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 5-(trifluoromethyl)isoindoline for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.58 (t, J=12.0, 4H), 7.42 (dd, J=8.2, 20.4, 3H), 4.91 (d, J=16.7, 4H), 4.23 (dd, J=16.2, 36.5, 2H), 3.83 (t, J=8.3, 1H), 3.77-3.62 (m, 2H), 2.74-2.54 (m, 1H), 2.32-2.16 (m, 1H); MS (DCI) m/z 457.1 (M+H)+.