反应详情

A solution of 5-(4,4,4-trifluoro-1-methoxymethylene-butyl)-2-(4-trifluoromethyl-phenyl)-pyridine (4.1 g, 10.9 mmol) and tetrahydrofuran (50 mL) is treated with concentrated hydrochloric acid (5 mL) and heated to reflux under nitrogen. The reaction is monitored by HPLC and allowed to cool upon completion. The solution is neutralized with 20% NaOH solution and diluted with diethyl ether. The two phases are separated and the organic layer washed with brine and water. The organic layer is dried over anhydrous sodium sulfate, filtered, and concentrated. Chromatography gives purified 5,5,5-trifluoro-2-[6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-pentanal (3.6 g, 10 mmol) 79% yield.

1. temperatureheated
2. temperatureto reflux under nitrogen
3. temperatureto cool upon completion
4. customThe two phases are separated
5. washthe organic layer washed with brine and water
6. dry with materialThe organic layer is dried over anhydrous sodium sulfate
7. filtrationfiltered
8. concentrationconcentrated
9. customChromatography gives