反应详情

To a mixture of 0.50 g of 4-hydroxy-3-[3-[3-[(methoxycarbonyl)methoxy]phenyl]-1-oxo-2-propenyl]-2(1H)-quinolinone and 15 ml of methanol was added dropwise 15 ml of a 1 N aqueous sodium hydroxide solution under ice-cooling. After stirred for 1 hour under ice-cooling, this was concentrated under reduced pressure. The resulting residue was acidified by addition of 2 N hydrochloric acid under ice-cooling, and precipitated crystals were filtered, and washed with tetrahydrofuran to obtain 0.46 g of 4-hydroxy-3-[3-[3-(carboxymethoxy)phenyl]-1-oxo-2-propenyl]-2(1H)-quinolinone [Compound No. (9e)] as a yellow crystal.

1. temperaturecooling
2. temperaturecooling
3. concentrationthis was concentrated under reduced pressure
4. additionThe resulting residue was acidified by addition of 2 N hydrochloric acid under ice-
5. temperaturecooling
6. customprecipitated crystals
7. filtrationwere filtered
8. washwashed with tetrahydrofuran