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HRID1669559

反应详情

EQUATION

反应方程式

HRID 1669559 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)NS(=O)(=O)C6CC6)CC5C=CCCCCCCC(=O)N4C3)cc(-c3nc(C(C)C)cs3)nc2c1
HCID67318810

未命名化合物

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCCCC(=O)N4C3)cc(-c3nccs3)nc2c1
HCID67320217

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)NS(=O)(=O)C6CC6)CC5C=CCCCCCCC(=O)N4C3)cc(-c3nccs3)nc2c1
HCID67319286

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 18-[7-methoxy-2-(thiazol-2-yl)quinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid (31) following the procedure reported for synthesis of N-[[18-[2-[4-(isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-4-yl]carbonyl](cyclopropyl)sulfonamide 11: m/z=694 (M+H)+. 1H NMR (CDCl3): 0.90-1.5 (m, 9H), 1.6-1.8 (m, 8H), 2.1-2.4 (m, 2H), 2.45-2.55 (m, 2H), 2.6-2.7 (m, 1H), 2.9-3 (m, 1H), 3.9 (s, 3H), 4.12 (dd, J=11.6 Hz, J=3.7 Hz, 1H), 5.1 (t, J=7.9 Hz, 1H), 5.00 (t, J=9 Hz, 1H), 5.48 (t, J=2.9 Hz, 1H), 5.7 (dd, J=18.2 Hz, J=8.8 Hz, 1H), 7 (br s, 1H), 7.15 (dd, J=9.1 Hz, J=2.4 Hz, 1H), 7.4 (d, J=2.4 Hz, 1H), 7.5 (d, J=3.2 Hz, 1H), 7.59 (s, 1H), 7.9 (d, J=3.2 Hz, 1H), 7.9 (d, J=9.1 Hz, 1H), 10.3 (br s, 1H).