反应详情

A mixture of 2-aminopyridine (I1) (1.0 equiv., 5.30 mmol, 0.500 g), 4-nitrophenyl isocyanide (I2) (1.1 equiv., 5.80 mmol, 0.870 g), methyl 2-formylbenzoate (13) (1.1 equiv., 5.80 mmol, 0.960 g) and perchloric acid (0.1 equiv., 0.53 mmol, 0.053 g) in methanol (25 ml) was stirred at room temperature until no starting material was left. The progress of the reaction was monitored by LCMS. Potassium tert-butoxide (1.1 equiv., 5.80 mmol, 0.660 g) was added and the reaction mixture was further stirred at room temperature for 2 h. The resulting precipitate was filtered off and washed with isopropanol and isopropyl ether to give 6-(4-nitrophenyl)-pyrido[2′,1′:2,3]imidazo-[4,5-c]isoquinolin-5(6H)-one (1) (1.20 g, yield=63%, purity (LC)=95%).

1. waitwas left
2. stirringthe reaction mixture was further stirred at room temperature for 2 h
3. filtrationThe resulting precipitate was filtered off
4. washwashed with isopropanol and isopropyl ether