HCID 57989938, compound → HCID 57989700, compound

HRID 1671124Notes

Reaction equation

HRID 1671124 reaction equation
ClC1N=C(C2SC(C(C)C)=NC=2C2C=C(C=CC=2)N)C=CN=1.[Cl:23][C:24]1[N:29]=[C:28]([C:30]2[S:34][C:33]([N:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)=[N:32][C:31]=2[C:41]2[C:42]([F:55])=[C:43]([NH:48]C(=O)OCC=C)[CH:44]=[CH:45][C:46]=2[F:47])[CH:27]=[CH:26][N:25]=1>>[Cl:23][C:24]1[N:29]=[C:28]([C:30]2[S:34][C:33]([N:35]3[CH2:36][CH2:37][O:38][CH2:39][CH2:40]3)=[N:32][C:31]=2[C:41]2[C:42]([F:55])=[C:43]([CH:44]=[CH:45][C:46]=2[F:47])[NH2:48])[CH:27]=[CH:26][N:25]=1

Participants

3

Reactant 2

HCID 57989938HCID 57989938, compoundHCID 579900463-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]aniline

Product 1

HCID 57989700HCID 57989700, compoundYield 64%

Procedure

Following a procedure analogous to the procedure described in Intermediate 13 using 2-propen-1-yl {3-[5-(2-chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}carbamate (5.11 g, 10.35 mmol) the title compound of Step G was obtained as a light yellow solid (2.71 g 64% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 8.44 (d, J=5.5 Hz, 1H), 6.90-7.00 (m, 2H), 6.73 (d, J=5.5 Hz, 1H), 5.23 (s, 2H), 3.71-3.76 (m, 4H), 3.54-3.60 (m, 4H). MS (ESI): 409 [M+H]+.

Sources & evidence

ORD record
ord-13e52ccdcac64d2eae57df50dff84929
Source dataset
uspto-grants-2011_08
Patent number
US07994185B2

Reaction notes

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