反应详情

A solution of 11.7 g (32.65 mmol) of [2-(4′-trifluoromethylbiphenyl-4-ylmethoxy)phenyl]-methanol from Example 24A in 100 ml of acetonitrile is mixed with 10.64 g (31.02 mmol) of triphenylphosphonium hydrobromide and heated to reflux for 3 hours. The reaction solution is then concentrated to dryness, and the resulting oil is taken up and triturated in diethyl ether. The product crystallizes as a white solid during this. After filtration, the solid is dried in a oven at 50° C. overnight. 20.5 g (30 mmol, 92% yield) of crystalline product are obtained.

1. temperatureheated
2. temperatureto reflux for 3 hours
3. concentrationThe reaction solution is then concentrated to dryness
4. customtriturated in diethyl ether
5. customThe product crystallizes as a white solid during this
6. filtrationAfter filtration
7. customthe solid is dried in a oven at 50° C. overnight