反应详情

1.7 g (5.41 mmol) of {5-fluoro-2-[2-(4-trifluoromethylphenyl)ethoxy]phenyl}methanol and 1.76 g (5.14 mmol) of triphenylphosphonium hydrobromide are heated under reflux in 20 ml of acetonitrile for three hours. A first product fraction is crystallized at −20° C. The mother liquor is concentrated, the residue is dissolved in dichloromethane, and a second fraction is crystallized with diethyl ether. A total of 2.71 g (76% yield) of the title compound is obtained.

1. customA first product fraction is crystallized at −20° C
2. concentrationThe mother liquor is concentrated
3. dissolutionthe residue is dissolved in dichloromethane
4. customa second fraction is crystallized with diethyl ether