Sodium Hydroxide → 1-[(2R)-oxiranylmethyl]-4-methanesulfonylpiperazine

Sodium hydroxide (1.07 g, 26.7 mmol) was added to a vigorously stirred solution of 1-chloro-(R)-2-hydroxy-3-(4-methanesulfonylpiperazin-1-yl)propane, the product of the previous step (5.69 g, 22.2 mmol) in THF/water (150 mL/35 mL). The reaction mixture was stirred for 35 min, concentrated in vacuo to approximately 50 mL volume, diluted with chloroform (200 mL), and washed with 1M NaOH (2×70 mL) and brine (70 mL). The organic layer was dried (MgSO4), filtered and concentrated in vacuo to yield a white crystalline solid which was then recrystallised from hot EtOAc/hexane 1:1 (800 mL) to yield the title intermediate (2.62 g) as a white crystalline solid. (The filtrate could be further recrystallised to obtain additional product material.) ESMS (C8H16N2O3S): calcd. 221.10; found 221.3 (m/z): [M+H]+; 1H NMR (DMSO-d6): δ (ppm) 2.22 (dd, 1H), 2.45-2.60 (m, 5H), 2.69-2.75 (m, 2H), 2.87 (s, 3H), 3.02 (m, 1H), 3.11 (m, 4H).

1. concentrationconcentrated in vacuo to approximately 50 mL volume
2. additiondiluted with chloroform (200 mL)
3. washwashed with 1M NaOH (2×70 mL) and brine (70 mL)
4. dry with materialThe organic layer was dried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. customto yield a white crystalline solid which
8. customwas then recrystallised from hot EtOAc/hexane 1:1 (800 mL)

ORD record

ord-abc69c80408e4abe9aa8dac8aad850f7

Source dataset

uspto-grants-2011_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08003664B2