HRID1677796

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7730

Benzene, 1-bromo-4-methoxy-

C7H7BrO

HCID31169

Piperidine, 4-propyl-

C8H17N

结构：CC(C)C[C@H](C(=O)N1CCN(c2nc(-c3ccccc3)ns2)CC1)[C@H](O)C(=O)NO

HCID11604459

未命名化合物

结构：COc1ccc(CCC[C@@H](C(=O)O)[C@@H]2OC(C)(C)OC2=O)cc1

HCID67335259

未命名化合物

PRODUCTS

生成物

结构：CCCC1CCN(C(=O)[C@H](CCCc2ccc(OC)cc2)[C@H](O)C(=O)NO)CC1

HCID58487963

未命名化合物

PROCEDURE

实验过程

The title product was prepared following the procedure of Example 64 (step a and b) but starting from (2R)-2-[(4S)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-5-(4-methoxyphenyl)pentanoic acid (prepared following the procedure of Intermediate 2 but using 4-bromoanisole in step b) and 4-propylpiperidine (Aldrich). Purification by reverse-phase chromatography gave the title product as a yellow powder. M−(ESI): 405.4; M+(ESI): 407.4. HPLC (Condition A): Rt: 3.6 min (HPLC purity: 94.9%).

WORKUP

后处理

customThe title product was prepared
customprepared
customPurification by reverse-phase chromatography