反应详情

温度

42.5 °C

To a soluton of 2,2,2-trichloroethyl α-[4-cyclopropylmethoxycarbonylthio-3-phenoxyacetamido-2-oxoazetidin-1-yl]-α-[2-bromo-1-(piperidin-1-yl)ethylidene]acetate (573 mg) in methanol (30 ml) is added 10% hydrochloric acid (7 ml), and the mixture is stirred at room temperature or at 40 to 45° C. After 30 minutes, the reaction mixture is poured into ice water, and is extracted with benzene. The extract solution is washed with water, dried, and evaporated to give 2,2,2-trichloroethyl α-[4-cyclopropylmethoxycarbonylthio-3-phenoxyacetamido-2-oxoazetidin-1-yl]-α-(2-bromo-1-hydroxyethylidene)-acetate (434 mg). Yield: 83.5%. IR: νmaxCHC13 3450, 1790, 1720, 1720 (sh), 1700 cm-1. NMR: δCDC13 0.1-1.4m7H, 3.98d(7Hz)2H, 4.27d(5Hz)2H, 4.57s2H, 4.82d(3Hz)2H, 5.27d(6;8Hz)1H, 5.93d(5Hz)1H, 6.8-7.5m6H, 11.67brs1H.

1. extractionis extracted with benzene
2. washThe extract solution is washed with water
3. customdried
4. customevaporated