反应详情

Obtained using the procedure described in section b of Example 9, starting with 5.5 g (0.0194 mole) of 4-amino-2-[(4-methoxyphenoxy)methyl]pteridine in 150 ml of 5% aqueous sodium hydroxide. The solid obtained is taken up in dilute sodium hydroxide for purification. The insoluble portion is removed by filtration. The filtrate is acidified with acetic acid to pH 5.5. The precipitate formed is isolated by filtration; it is finally recrystallized from a mixture of ethanol and N,N-dimethylformamaide. Yld: 1.7 g (31%), m.p. 233°-234° C.

1. customObtained
2. customThe solid obtained
3. customis taken up in dilute sodium hydroxide for purification
4. customThe insoluble portion is removed by filtration
5. customThe precipitate formed
6. customis isolated by filtration
7. customit is finally recrystallized from a mixture of ethanol and N,N-dimethylformamaide