N-methyl-2-pyrrolidone → 2-{2-[(2E)-3-(Methoxycarbonyl)prop-2-enoyloxy]acetylamino}acetic acid

HRID 1685613Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1685613
[C:1]([O:8][CH3:9])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[C:10](=[O:13])([O-])[OH:11].[Cs+].[CH3:15][N:16]1[C:20](=[O:21])[CH2:19]CC1>>[CH3:9][O:8][C:1](/[CH:2]=[CH:3]/[C:4]([O:6][CH2:19][C:20]([NH:16][CH2:15][C:10]([OH:11])=[O:13])=[O:21])=[O:5])=[O:7]

Komponenten

4

Edukt 3

HCID 13387N-methyl-2-pyrrolidoneHCID 2734983Cesium bicarbonateHCID 5369209Monomethyl Fumarate

Produkt 1

HCID 461791542-{2-[(2E)-3-(Methoxycarbonyl)prop-2-enoyloxy]acetylamino}acetic acidAusbeute 12 %

Versuchsvorschrift

Following general procedure A, methyl hydrogen fumarate (MHF) (0.68 g, 5.26 mmol) dissolved in NMP was reacted at ca. 55° C. with tert-butyl 2-(2-chloroacetylamino) acetate (0.91 g, 4.38 mmol) in the presence of CsHCO3 (1.19 g, 6.13 mmol) of the tert-butyl-protected intermediate and then purified by silica gel column chromatography (Biotage) using a mixture of ethyl acetate (EtOAc) and hexanes (1:2 to 2:3 to 1:1) as eluent. The purified product was treated with 50% trifluoroacetic acid (TFA) in dichloromethane (DCM). Removal of solvents afforded 0.13 g (12% yield) of the title compound (6). 1H NMR (CD3OD, 400 MHz): δ 6.96-6.93 (m, 2H), 4.74 (s, 2H), 3.98-3.95 (m, 2H), 3.81 (s, 3H). MS (ESI): m/z 246.00 (M+H)+, 244.02 (M−H)−.

Aufarbeitung

  1. custompurified by silica gel column chromatography (Biotage)
  2. additiona mixture of ethyl acetate (EtOAc) and hexanes (1:2 to 2:3 to 1:1) as eluent
  3. additionThe purified product was treated with 50% trifluoroacetic acid (TFA) in dichloromethane (DCM)
  4. customRemoval of solvents

Quellen und Nachweise

ORD-Eintrag
ord-ece98036c6914c64b591291a897b8782
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148414B2

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