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HRID1687503

反应详情

EQUATION

反应方程式

HRID 1687503 的结构方程式

REACTANTS

反应物

2
结构：COCCN1CCc2ccc(N)cc2CC1
HCID57416089

3-(2-Methoxyethyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-amine

C13H20N2O

结构：NC(=O)[C@@H]1[C@H](Nc2nc(Cl)ncc2C(F)(F)F)[C@H]2C=C[C@@H]1C2
HCID86633950

未命名化合物

PRODUCTS

生成物

1
结构：COCCN1CCc2ccc(Nc3ncc(C(F)(F)F)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)cc2CC1
HCID67263923

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from (1S,2S,3R,4R)-3-(2-Chloro-5-trifluoromethylpyrimidin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine in an analogous manner to Example 933 to afford a yellow solid (41 mg, 70%). Mp: 125-7° C. LCMS (m/e) 517 (M+1); 1H-NMR (CDCl3, 400 MHz) δ 8.13 (s, 1H), 7.48 (d, J=8 Hz, 1H), 7.37-7.17 (m, 3H), 7.05 (d, J=8 Hz, 1H), 6.32 (m, 2H), 6.85 (br s, 1H), 6.63 (br s, 1H), 4.40 (m, 1H), 3.59 (m, 2H), 3.38 (s, 3H), 3.09 (s, 1H), 2.84 (m, 5H), 3.76 (m, 6H), 2.45 (d, J=8 Hz, 1H), 2.20 (d, J=8 Hz, 1H), 1.62 (d, J=8 Hz, 1H).